TB500
Thymosin Beta 500
TB-500 is a synthetic version of a natural protein called Thymosin Beta-4, which is found in almost every tissue of the body and plays a key role in tissue repair, cell migration, and inflammation control. It works by promoting the growth of new blood vessels, encouraging healthy cell movement, and reducing the buildup of scar tissue. This makes TB-500 especially valuable for healing injuries, particularly in muscles, tendons, ligaments, and joints. Athletes and individuals recovering from physical trauma often use TB-500 to speed up recovery and support full tissue regeneration.
In addition to its injury-repair benefits, TB-500 may help improve flexibility, endurance, and muscle tone by enhancing cellular function and reducing inflammation systemically. It has also shown potential in promoting hair growth and improving heart tissue health in early studies. TB-500 is usually administered by subcutaneous or intramuscular injection and is often stacked with other regenerative peptides like BPC-157 for a synergistic effect. Because it supports overall healing and regeneration, it is commonly used in performance medicine and longevity protocols focused on resilience and recovery.
Protocols
1. Injury Recovery & Tissue Regeneration
Dosage: 2–5 mg per injection, 2 times per week
Cycle: 4–6 weeks, followed by reassessment
Administration: Subcutaneous (SC) or intramuscular (IM) injection, ideally near the injury site
Stacking: Works well with BPC-157 for synergistic healing effects
Expected Benefits: Faster healing of muscles, tendons, ligaments, and joints
2. Muscle Growth & Performance Recovery
Dosage: 2–5 mg per injection, 2 times per week
Cycle: 4–8 weeks, repeated as needed
Administration: SC or IM injection
Stacking: Often combined with IGF-1 LR3, CJC-1295, or GH peptides
Expected Benefits: Improved muscle recovery, enhanced flexibility, reduced fatigue
3. Joint & Tendon Repair (Tendinitis, Arthritis, Ligament Damage)
Dosage: 2–5 mg per injection, 2 times per week
Cycle: 4–8 weeks, followed by a break
Administration: SC or IM injection
Stacking: Best paired with BPC-157 and Collagen Peptides
Expected Benefits: Reduced joint pain, improved collagen formation, better mobility
4. Wound Healing & Skin Regeneration
Dosage: 2–3 mg per injection, 2 times per week
Cycle: 4–6 weeks
Administration: SC injection or topical application (for skin wounds)
Stacking: Often used with GHK-Cu for skin rejuvenation
Expected Benefits: Faster wound closure, reduced scar formation, improved skin elasticity
5. Heart & Cardiovascular Health
Dosage: 2–3 mg per injection, 2 times per week
Cycle: 6–12 weeks
Administration: SC or IM injection
Stacking: Works well with MOTS-c, CoQ10, and Taurine for heart support
Expected Benefits: Improved blood vessel function, reduced fibrosis, enhanced cardiac repair
Further reading
TB-500 exerts its effects primarily through its ability to modulate actin, a key protein responsible for cellular movement, repair, and migration. This makes it highly effective in promoting tissue healing, reducing inflammation, and improving flexibility.
It has shown significant potential in:
Regenerating damaged muscle, tendon, and ligament tissue
Promoting new blood vessel growth (angiogenesis) for enhanced circulation
Reducing inflammation and oxidative stress
Preventing excessive scar tissue formation (fibrosis)
Unlike BPC-157, which mainly functions by increasing blood flow and gut healing, TB-500’s primary role is in cellular movement and structural repair, making it particularly effective for deep tissue healing and chronic injuries.
TB-500 has also shown promise in neuroprotection and organ repair, particularly in conditions affecting the heart, liver, and brain. However, further research is needed to establish optimal dosing and long-term safety in humans.
Potential Side Effects
Mild fatigue or dizziness (rare)
Temporary muscle cramps or tightness
Possible headaches (dose-dependent)
Increased hair/nail growth (due to enhanced cellular activity)
TB-500 is well-tolerated with a low risk of toxicity, making it a safe long-term option for regenerative support.
References
- Badamchian, M., et al. (2003). "Thymosin beta-4 and its role in tissue regeneration and wound healing." Annals of the New York Academy of Sciences, 994, 141–154.
Xie, F., et al. (2013). "Thymosin beta-4 accelerates wound healing and reduces inflammation." Journal of Molecular Medicine, 91(6), 765–776.
Goldstein, A. L., et al. (2012). "Thymosin beta-4: A potential therapy for neurodegenerative diseases." Neuroscience Letters, 519(1), 1–7.
Bock-Marquette, I., et al. (2004). "Thymosin beta-4 activates integrin-linked kinase to promote cardiac repair." Nature, 432(7015), 466–472.
Philp, D., et al. (2007). "Thymosin beta-4 and its role in the repair and regeneration of tissues." Expert Opinion on Biological Therapy, 7(4), 513–522.