Pinaelon
Tripeptide Derived from Pineal Gland
Pinealon is a short synthetic peptide composed of just three amino acids, designed to support brain health, cognitive function, and neuroprotection, especially during aging or after neurological stress. It mimics natural compounds found in the pineal gland, which plays a central role in regulating circadian rhythms, hormonal balance, and brain signaling. Pinealon helps protect neurons from oxidative stress and improves cellular energy production in the brain, which is essential for maintaining mental clarity, memory, and focus.
Research suggests Pinealon may be beneficial in conditions involving cognitive decline, brain fog, fatigue, or neurodegenerative disorders. It’s also been studied for its potential to protect brain cells after trauma or stroke, and may even support mood stability. Because of its small size, Pinealon crosses the blood-brain barrier easily, allowing it to act directly on brain tissue. It is typically used in nootropic or anti-aging protocols to enhance mental performance, improve recovery, and support long-term brain resilience.
Protocols
1. Cognitive Enhancement & Memory Improvement
Dosage: 100–200 mcg per injection or oral administration, once daily
Cycle: 10–20 days, repeated every 3–6 months as needed
Administration: Subcutaneous (SC) injection or sublingual for oral absorption
Stacking: Often combined with Cerebrolysin, Semax, or Dihexa for enhanced neuroprotection
Expected Benefits: Improved memory recall, enhanced focus, better learning ability
2. Neuroprotection & Anti-Ageing (Alzheimer’s & Parkinson’s Support)
Dosage: 200 mcg per injection, once daily
Cycle: 10–30 days, depending on severity of cognitive impairment
Administration: SC injection or oral intake
Stacking: Works well with Epitalon and NA-1 (Tat-NR2B9c) for neurodegenerative protection
Expected Benefits: Slowed cognitive decline, improved neuronal resilience, better synaptic plasticity
3. Mood Enhancement & Stress Reduction
Dosage: 100–200 mcg per injection, once daily
Cycle: 10–20 days, with reassessment
Administration: SC injection or sublingual
Stacking: Can be used alongside Selank or Noopept for enhanced mood regulation
Expected Benefits: Reduced anxiety, stabilised mood, improved stress resilience
4. Sleep Optimisation & Circadian Rhythm Regulation
Dosage: 100 mcg per injection, taken in the evening
Cycle: 10–20 days, as needed
Administration: SC injection or sublingual
Stacking: Often combined with Epitalon or Melatonin for sleep enhancement
Expected Benefits: Improved sleep quality, balanced melatonin secretion, better circadian rhythm stability
Further reading
Pinealon functions at the epigenetic level, influencing gene expression related to brain plasticity, oxidative stress resistance, and mitochondrial energy production. Studies suggest it can upregulate BDNF (Brain-Derived Neurotrophic Factor), a key protein in synaptic plasticity and cognitive resilience. This makes Pinealon particularly useful in preventing age-related cognitive decline and neurodegeneration.
Another significant effect of Pinealon is its role in regulating the pineal gland, which produces melatonin—the hormone responsible for sleep-wake cycles and circadian rhythm. This connection explains why Pinealon may enhance deep sleep quality and overall mental clarity.
Compared to synthetic nootropics that act as stimulants, Pinealon’s peptide bioregulation mechanism restores natural cognitive function without excessive neurotransmitter activation. This makes it an ideal choice for long-term cognitive support, particularly in older adults or individuals experiencing high levels of cognitive stress.
Despite its promising benefits, research on Pinealon remains limited outside of Russia. While early clinical trials have demonstrated improvements in memory, neuroprotection, and stress adaptation, larger studies are needed to fully understand its long-term impact and potential interactions with other neurological treatments.
References
- Khavinson, V. K., & Tarnovskaya, S. I. (2001). "Peptide bioregulators and ageing: Mechanisms of action and prospects for clinical application." Biogerontology, 2(2), 97–105.
Anisimov, V. N., et al. (2011). "Effect of peptide bioregulators on life span and cognitive function in aged animals." Mechanisms of Ageing and Development, 132(3), 137–143.
Morozov, V. G., et al. (2009). "Short peptides and their effects on neurodegeneration and stress adaptation." Journal of Neuroscience Research, 123(2), 151–165.
Khavinson, V. K., et al. (2016). "Neuroprotective effects of Pinealon and its role in cognitive ageing." Aging Research Reviews, 30, 39–52.
Alimova, I. N., & Khavinson, V. K. (2018). "The role of short peptides in sleep regulation and circadian balance." Neuroscience & Behavioral Physiology, 48(5), 590–597.