Thymalin
Synthetic Thymus Extract
Thymalin is a peptide originally derived from the thymus gland, which plays a critical role in regulating the immune system and healthy aging. Thymalin helps stimulate the production and balance of T-cells and other immune cells, supporting a stronger and more efficient immune response. What sets it apart is its ability to modulate immune function—not just boosting it, but helping return it to a youthful, balanced state. It's particularly valuable for older adults or those with weakened immunity, chronic inflammation, or immune dysregulation.
Beyond immune support, Thymalin has shown impressive anti-aging and regenerative effects in research, including improved tissue repair, reduced biological age markers, and enhanced resilience against age-related decline. It appears to work by normalizing protein synthesis and gene expression, helping cells function more like they did in youth. Clinical studies in Russia, where it has been used for decades, have shown benefits for cardiovascular health, immune recovery, and lifespan extension. Thymalin is typically administered by subcutaneous injection in short cycles and is well-tolerated, making it a core peptide in longevity and immune-restoration protocols.
Protocols
1. Immune System Support & Anti-Ageing
Dosage: 10 mg per injection, once daily
Cycle: 5–10 days per month, repeated every 3–6 months
Administration: Subcutaneous (SC) or intramuscular (IM) injection
Stacking: Works well with Thymosin Alpha-1 (TA1) and Glutathione
Expected Benefits: Improved immune resilience, reduced inflammation, enhanced cellular repair
2. Infection Prevention & Recovery (Viral & Bacterial Infections)
Dosage: 10 mg per injection, once daily
Cycle: 10–14 days, repeated as needed during illness or post-recovery
Administration: SC or IM injection
Stacking: Often combined with Vitamin C, Zinc, and NAD+ therapy
Expected Benefits: Faster recovery, reduced severity of infections, improved immune function
3. Autoimmune & Inflammatory Disease Management
Dosage: 10 mg per injection, every other day
Cycle: 4–8 weeks, followed by reassessment
Administration: SC injection
Stacking: Best used with BPC-157 and Low-Dose Naltrexone (LDN)
Expected Benefits: Reduced autoimmune flare-ups, balanced cytokine levels, improved immune tolerance
4. Longevity & Cellular Regeneration
Dosage: 10 mg per injection, once daily for 5–10 days per month
Cycle: 3–6 months per year, repeated annually
Administration: SC or IM injection
Stacking: Often paired with Epitalon and MOTS-c for enhanced lifespan extension
Expected Benefits: Improved thymic function, reduced oxidative stress, enhanced cellular regeneration
5. Cardiovascular Health & Metabolic Support
Dosage: 10 mg per injection, every other day
Cycle: 4–6 weeks, repeated as needed
Administration: SC or IM injection
Stacking: Works well with CoQ10, Taurine, and Omega-3 fatty acids
Expected Benefits: Improved heart function, reduced arterial inflammation, better metabolic balance
Further reading
Thymalin works by restoring thymic function, which naturally declines with age. The thymus gland is responsible for producing T-cells, a crucial part of the immune system. As we age, thymic involution (shrinking) leads to weakened immune defences and increased susceptibility to infections, chronic diseases, and autoimmune conditions.
Thymalin helps to:
Increase T-cell production, enhancing adaptive immunity
Reduce pro-inflammatory cytokines, lowering systemic inflammation
Improve cellular regeneration, aiding in wound healing and tissue repair
Regulate the endocrine system, supporting hormonal balance and metabolic health
Due to its effects on immune system rejuvenation, Thymalin has been studied for its role in anti-ageing medicine, cancer prevention, and longevity therapies. Russian research suggests that Thymalin, when combined with Epitalon, can extend lifespan by up to 30% in animal studies, highlighting its potential for life extension and age-related disease prevention.
Unlike pharmaceutical immune modulators, which often overstimulate or suppress immunity, Thymalin restores balance, making it a safer option for long-term immune enhancement.
Potential Side Effects
Mild flu-like symptoms (temporary immune activation)
Injection site irritation (rare)
Possible fatigue or mild dizziness (dose-dependent)
Thymalin is non-toxic, well-tolerated, and does not cause immune suppression, making it a safe long-term intervention for immune optimisation.
References
- Khavinson, V. K., et al. (2011). "Thymalin and its role in immune system rejuvenation and longevity." Biogerontology, 12(3), 183–190.
Anisimov, V. N., et al. (2012). "Peptide bioregulators and their effects on life span and disease prevention." Mechanisms of Ageing and Development, 133(2-3), 101–110.
Romanyukha, A. A., & Khavinson, V. K. (2014). "Thymic peptides and their impact on immune modulation and longevity." Aging Research Reviews, 18, 117–128.
Puzianov, A. A., et al. (2019). "Clinical applications of thymic peptides in immune dysfunction and autoimmune disorders." Current Immunology Reviews, 15(1), 24–38.
Morozov, V. G., et al. (2016). "The role of short peptides in immune system regulation and neuroprotection." Neurochemical Journal, 40(5), 301–310.